Combination immunotherapy: a road map

Combination immunotherapy: a road map

Cancer immunotherapy and in particular monoclonal antibodies blocking the inhibitory programed cell death 1 pathway (PD-1/PD-L1) have made a significant impact on the treatment of cancer patients in recent years. However, despite the remarkable clinical efficacy of these agents in a number of malignancies, it has become clear that they are not sufficiently active for many patients. Initial evid...

A Road Map

Researchers in the organizational sciences and in the social and behavioral sciences in general encounter a host of problems as they seek to describe, predict, and understand behavior. The procedures we use to measure and analyze behavior are constantly improving as a result of the efforts of psychometricians and applied statisticians, among others. Many of the techniques discussed in this book...

Algorithmic Debugging: A Road Map

Software Evolution: A Road Map

The aim of the panel session is to clarify issues involved in software evolution, but more particularly, to identify and explore promising solutions and research directions, in order to identify strategic goals for the research community and solution visions for practitioners. By evolution, we mean a stage of software lifecycle where the software undergoes substantial changes and this also incl...

Repair road map

A report on page 195 by BekkerJensen et al. maps out the damage-induced rearrangement of proteins involved in repairing doublestranded DNA breaks (DSBs). The map, the authors hope, will help scientists assign functions to future putative damageresponsive proteins. Treatments such as ionizing radiation (and chemotherapy) that induce DSBs lead to the accumulation of nuclear foci containing repair...